abstract：:Interindividual differences in cytochrome P450 (CYP) 2C19 activity may result in variations in the therapeutic response to drugs metabolized by this enzyme. Differences at gene level may translate into protein level with consequent impairment of the enzyme activity. As a result patients with such genetic differences m...

authors： Ahmed S,Gul S,Akhlaq M,Hussain A,Tariq Khan S,Rehman H,Hanif Bangash M,Al Mughairbi F,Hamid Hamdard M

更新日期：2021-12-01 00:00:00

abstract：:Myocardial ischemia/hypoxia-reperfusion injury mediates the progression of multiple cardiovascular diseases. It has been reported that knockdown of adaptor protein containing a PH domain, PTB domain and leucine zipper motif 1 (APPL1) is a significant factor for the progression of myocardial injury. However, the role o...

authors： Bai L,Yang J,Zhang H,Liao W,Cen Y

更新日期：2021-12-01 00:00:00

abstract：:Vitrification by the Cryotop method is frequently used for bovine oocyte cryopreservation. Nevertheless, vitrified oocytes still have reduced developmental competency compared with fresh counterparts. The objective of this study was to compare the effect of vitrification either at the germinal vesicle (GV) stage or at...

authors： Yodrug T,Parnpai R,Hirao Y,Somfai T

更新日期：2021-12-01 00:00:00

abstract：:Patient and public involvement is widely thought to be important in the improvement of health care delivery and in health equity.Purpose: The article examines the role of experiential knowledge in service co-production in order to develop opiate substitution treatment services (OST) for high-risk opioid users.Method: ...

authors： Palukka H,Haapakorpi A,Auvinen P,Parviainen J

更新日期：2021-12-01 00:00:00

abstract：:Spontaneous senile osteoporosis severely threatens the health of the senior population which has emerged as a severe issue for society. A SAMP6 mouse model was utilized to estimate the impact of intragastrically administered Astragalus Membranaceus (AR) on spontaneous senile osteoporosis. Bone mineral density (BMD) an...

authors： Chai Y,Pu X,Wu Y,Tian X,Li Q,Zeng F,Wang J,Gao J,Gong H,Chen Y

更新日期：2021-12-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. Currently, we lack effective risk models for the prognosis of ccRCC patients. Given the significant role of cancer immunity in ccRCC, we aimed to establish a novel united risk model including clinical stage and immune-related gene pair...

authors： Tao Z,Zhang E,Li L,Zheng J,Zhao Y,Chen X

更新日期：2021-12-01 00:00:00

abstract：:This case illustrates a false positive F18 FDG PET CT in the left axilla of a woman being treated for metastatic breast cancer after COVID-19 vaccination. Follow-up ultrasound of the axilla indicated no metastasis, indicating that the lymphadenopathy was likely due to an immune response following vaccination. This cas...

authors： Schapiro R,Moncayo VM,Meisel JL

更新日期：2021-12-01 00:00:00

abstract：:To study the regulation of miR-148a-3p on CDK6 and its mechanism in the progress of acute myeloid leukemia (AML), differential miRNAs were analyzed by bioinformatics, and the miR-148a-3p levels in AML cell lines were detected. Results showed that miR-148a-3p played a crucial role in AML, and the level was lower in AML...

authors： Zhou H,Jia X,Yang F,Shi P

更新日期：2021-12-01 00:00:00

abstract：:To prepare glutaraldehyde-based cross-linked medium molecular weight chitosan nanoparticles encapsulated with 5-Fluorouracil (5-FU), to overcome dosing frequency as well as reducing acute oral toxicity and poor bioavailability of the drug. Medium molecular weight chitosan nanoparticles (MMWCH-NPs) were prepared by rev...

authors： Sethi A,Ahmad M,Huma T,Ahmad W

更新日期：2021-12-01 00:00:00

abstract：:Endocannabinoids are a group of endogenous mediators derived from membrane lipids, which are implicated in a wide variety of physiological functions such as blood pressure regulation, immunity, pain, memory, reward, perception, reproduction, and sleep. N-Arachidonoylethanolamine (anandamide; AEA) and 2-arachidonoylgly...

authors： Lin YF

更新日期：2021-12-01 00:00:00

abstract：:The chemical structure of PF-07321332, the first orally available Covid-19 clinical candidate, has recently been revealed by Pfizer. No information has been provided about the interaction pattern between PF-07321332 and its biomolecular counterpart, the SARS-CoV-2 main protease (Mpro). In the present work, we exploite...

authors： Pavan M,Bolcato G,Bassani D,Sturlese M,Moro S

更新日期：2021-12-01 00:00:00

abstract：:Increasing evidence has confirmed the vital roles of circular RNAs (CircRNAs) in the drug resistance of breast cancer (BC). Herein, we intended to study the effect of circular RNA FAT atypical cadherin 1 (circFAT1) on BC oxaliplatin (OX) resistance and find out the potential molecular mechanism in it. In this study, m...

authors： Yao Y,Li X,Cheng L,Wu X,Wu B

更新日期：2021-12-01 00:00:00

abstract：:Researchers have demonstrated that long non-coding RNAs (lncRNAs) are vital in colorectal cancer (CRC) progression. Here, we aimed to explore the function of lncRNA PAX6 upstream antisense RNA (PAUPAR) in the development of CRC. In the present study, PAUPAR and microRNA (miR)-17-5p expression levels in CRC tissues and...

authors： Wen R,Chen C,Zhong X,Hu C

更新日期：2021-12-01 00:00:00

abstract：:G protein-coupled receptor 39 (GPR39) agonist weakens oxidized low-density lipoprotein (ox-LDL)-induced attachment of monocytes to vascular endothelial cells and thus alleviates atherosclerosis. This study looks at whether GPR39 protects macrophages against ox-LDL-induced inflammation and apoptosis and ameliorates lip...

authors： Chen L,Fang Z,Wang X,Sun X,Ge X,Cheng C,Hu H

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Early detection of acute kidney injury (AKI) is crucial for the prognosis of patients after liver transplantation (LT). This passage aims to analyze the perioperative clinical markers of AKI after LT and establish predictive models based on clinical variables for early detection of AKI after LT. ME...

authors： Xin W,Yi W,Liu H,Haixia L,Dongdong L,Ma Y,Li G

更新日期：2021-12-01 00:00:00

abstract：:Augmented reality (AR) is a relatively new technology that allows for digitally generated three-dimensional representations to be integrated with real environmental stimuli. AR can make use of smart phones, tablets, or other devices to achieve a highly stimulating learning environment and hands-on immersive experience...

authors： Dhar P,Rocks T,Samarasinghe RM,Stephenson G,Smith C

更新日期：2021-12-01 00:00:00

abstract：:Melanoma is a type of cancer with a relatively poor prognosis. The development of immunotherapy for the treatment of patients with melanoma has drawn considerable attention in recent years. It is of great clinical significance to identify novel promising prognostic biomarkers and to explore their roles in the immune m...

authors： Xie J,Zhu Z,Cao Y,Ruan S,Wang M,Shi J

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Inflammation is crucial in the pathogenesis of lower urinary tract symptoms (LUTS) in men. Diet modulates inflammation. Therefore, diet could be a modifiable factor in male LUTS prevention and treatment. We aimed to investigate the association between dietary inflammatory potential and male LUTS. METHODS:We...

authors： Liao X,Bian H,Zheng X,Ai J,Yang L,Liu L,Qiu S,Wei Q

更新日期：2021-12-01 00:00:00

abstract：:Recently, flexible electronic device technology has evolved beyond curved devices with the development of flexible/stretchable devices that can be crumpled or stretched. Both elasticity and durability are essential for these devices, which should have high-conductivity for antennas and repeatability for sensors. In ad...

authors： Jin Nam H,Yuk JH,Song K,Sun Kim Y,Nam SY,Park SH

更新日期：2021-12-01 00:00:00

abstract：:Nano-particulate matters (NPM) induced the lung injury in mice were evaluated using quantitative micro-computed tomography in the present article. It is an important negative effect of health problems that NPM exposure provokes changes in the lung injury. The micro-computed tomography (CT) to assess lung injury in mou...

authors： Mao M,Kong J,Chen K,Zhang J,Chen Z,Li J,Chang Y,Yuan H,Shi X,Chen G,Zhang J,Li J

更新日期：2021-12-01 00:00:00

abstract：:The aim of this study was to explore the neurocognitive effects of dexmedetomidine-loaded gold nanoparticles (AuNPs-dexmedetomidine) on anesthetized rats. Sixty Sprague Dawley rats (age, 2-3 weeks; weight, 250-280 g) were randomly divided into three groups (n = 20): the control group and two groups that received intra...

authors： Zhang X,Xing Z,Li J,Tang S,Zhang Y

更新日期：2021-12-01 00:00:00

abstract：:Two-cell stage and blastocyst stage mouse embryos were equilibrated in a medium containing 7.5% ethylene glycol (EG) and 7.5% dimethyl sulfoxide (DMSO) for 8-15 min. Vitrification was performed in a medium containing 0.5 M sucrose and either 15% EG + 15% DMSO, 17.5% EG + 17.5% DMSO, or 20% EG + 20% DMSO for 30 s. They...

authors： Suttirojpattana T,Juanpanich T,Parnpai R,Vutyavanich T

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Fibromyalgia (FM) is characterized by musculoskeletal pain, fatigue, sleep and memory disturbance. There is no definitive cure yet for FM-related health problems. Peroxisome proliferator-activated receptor's (PPAR's) activation is associated with insulin sensitisation and improved glucose metabolism. PPAR-γ ...

authors： Hassan FE,Sakr HI,Mohie PM,Suliman HS,Mohamed AS,Attia MH,Eid DM

更新日期：2021-12-01 00:00:00

abstract：:Facile preparation of a tumoral-stimuli-activated theranostic nanoparticle with simple constituents remains a challenge for tumor theranostic nanosystems. Herein we design a simple reductionresponsive turn-on theranostic nanoparticle for achieving fluorescent imaging and phototherapy combination. The theranostic nanop...

authors： Song X,Ruan L,Zheng T,Wei J,Zhang J,Lu H,Lu H,Hu Y,Chen J,Xue Y

更新日期：2021-12-01 00:00:00

abstract：:The Zn₃V₃O8 was synthesized by solvothermal method combined with heat treatment using Zn(NO₃)₃ · 6H₂O and NH₄VO₃ as raw materials. The Zn₃V₃O8 was doped by Co2+ to form Zn2.88Co0.12V₃O8. The samples were characterized by X-ray diffraction and scanning electron microscopy techniques. Electrochemical tests showed that t...

authors： Yuan ZY,Xiao Y,Yang XQ,Feng CQ

更新日期：2021-12-01 00:00:00

abstract：:Insertion or deletion of single copy of octapeptide repeat (OR) in human PrP protein are considered as polymorphism, while of insertions of more numbers of OR and deletion of two copies of OR are associated with genetic prion diseases.Here, we reported a 58-year-old female patient who displayed clinical manifestations...

authors： Shi Q,Shen XJ,Gao LP,Xiao K,Zhou W,Wang Y,Chen C,Dong XP

更新日期：2021-12-01 00:00:00

abstract：:Primary hippocampal neuronal cells were used to establish cell model of cerebral ischemia under oxygen-glucose deprivation (OGD) treatment. After the cell model was pre-treated with short hairpin (sh)-circ_NLRP1 or mmu-miR-199b-3p inhibitor, LDH release and cell apoptosis were detected by LDH kit and TUNEL staining, r...

authors： Sun B,Liu X,Peng H,Xiang X,Yang H

更新日期：2021-12-01 00:00:00

abstract：:Tuberculosis continues to be an important public health problem. Particularly considering Beijing-family strains of Mycobacterium tuberculosis, which have been associated with drug-resistance and hypervirulence. The Beijing-like SIT190 (BL) is the most prevalent Beijing strain in Colombia. The pathogenic mechanism and...

authors： María Irene CC,Juan Germán RC,Gamaliel LL,Dulce Adriana ME,Estela Isabel B,Brenda Nohemí MC,Payan Jorge B,Zyanya Lucía ZB,Myriam BDV,Fernanda CG,Adrian OL,Martha Isabel M,Rogelio HP

更新日期：2021-12-01 00:00:00

abstract：:Objectives: Sestrin2 is a stress-inducible protein and play an important role in adapting stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia-related diseases to provide new perspectives for future research and new therapeutic targets for hypoxia-related diseases.Methods: A review...

authors： Che X,Chai J,Fang Y,Zhang X,Zu A,Li L,Sun S,Yang W

更新日期：2021-12-01 00:00:00

abstract：:Glial vulnerability to prions is assessed in murine Creutzfeldt-Jakob disease (CJD) using the tg340 mouse line expressing four-fold human PrP M129 levels on a mouse PrP null background at different days following intracerebral inoculation of sCJD MM1 brain tissues homogenates. The mRNA expression of several astrocyte ...

authors： Andrés-Benito P,Carmona M,Douet JY,Cassard H,Andreoletti O,Ferrer I

更新日期：2021-12-01 00:00:00

abstract：:Purpose: One approach increasingly used by governments to deliver on public initiatives is to partner with private enterprise through public-private partnerships. This study is a qualitative process evaluation of an Australian state-wide workplace health programme "Get Healthy at Work" from the currently under-researc...

authors： Grunseit AC,Bohn-Goldbaum E,Thomas M,Seabury R,Rissel C,Crane M

更新日期：2021-12-01 00:00:00

abstract：:A new set of 4,6,7,8-tetrahydroquinolin-5(1H)-ones were designed as cytotoxic agents against breast cancer cell line (MCF-7) and synthesised under ultrasonic irradiation using chitosan decorated copper nanoparticles (CS/CuNPs) catalyst. The new compounds 4b, 4j, 4k, and 4e exhibited the most potent cytotoxic activity ...

authors： Mokhtar M,Alghamdi KS,Ahmed NS,Bakhotmah D,Saleh TS

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Huanglian Jiedu Decoction (HLJJD) has a variety of pharmacological activities, such as anti-inflammatory and neuroprotection against ischaemic brain injury. OBJECTIVES:This ex vivo study explores its antithrombosis activity and inhibition of platelet aggregation. MATERIAL AND METHODS:To study the antithrombos...

authors： Liu H,Chen X,Liu Y,Fang C,Chen S

更新日期：2021-12-01 00:00:00

abstract：:We propose two models inspired by the COVID-19 pandemic: a coupled disease-human behaviour (or disease-game theoretic), and a coupled disease-human behaviour-economic model, both of which account for the impact of social-distancing on disease control and economic growth. The models exhibit rich dynamical behaviour inc...

authors： Martcheva M,Tuncer N,Ngonghala CN

更新日期：2021-12-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) treatment offers support to new methods of transporting baseline cell protein endothelial cells in alginate (A)/silk sericin (SS) lamellar-coated antioxidant system (ASS@L) to promote acute myocardial infarction. In the synthesized frames of ASS, the ratio of fixity modules, pores, t...

authors： Long G,Wang Q,Li S,Tao J,Li B,Zhang X,Zhao X

更新日期：2021-12-01 00:00:00

abstract：:Sarcoma represents one of the most common malignant tumors with poor treatment outcomes and prognosis. Docetaxel (DTX) is acknowledged as one of the most important chemotherapy agents. The aim of this study was to improve the efficacy of docetaxel by incorporation into the mPEG-PLA nanoparticle (DTX NP) for the treatm...

authors： Chen J,Ning E,Wang Z,Jing Z,Wei G,Wang X,Ma P

更新日期：2021-12-01 00:00:00

abstract：:EMT-related gene expression reportedly exhibits correlation with the anti-tumor immunity of T cells. In the present study, we explored the factors that might affect the efficacy of immunotherapy in colon cancer with treatment. In this regard, RNA-seq and clinical data of 469 colon cancer samples derived from the Cance...

authors： Huang X,Chen C,Xu Y,Shen L,Chen Y,Su H

更新日期：2021-12-01 00:00:00

abstract：Background:The Shoulder Pain and Disability Index (SPADI) is the most commonly used self-administered questionnaire which is a valid and reliable instrument to assess the proportion of pain and disability in shoulder disorders. There is no evidence of SPADI questionnaire being translated into regional Indian language (...

authors： Pahade AJ,Wani SK,Mullerpatan RP,Elizabeth Roach K

更新日期：2021-12-01 00:00:00

abstract：:In the human body, joint cartilage is of great importance. It has long been a big therapeutic problem to fix joint cartilage lesions as it appears due to different conditions. Recent stories have shown that the cartilage replacement process must delay the extracellular (ECM) cartilage deterioration and modulate the ho...

authors： Li X,Lu Y,Wang Y,Zhou S,Li L,Zhao F

更新日期：2021-12-01 00:00:00

abstract：:Avian leukosis virus subgroup J (ALV-J) generally induces hemangioma, myeloid leukosis, and immunosuppression in chickens, causing significant poultry industry economic losses worldwide. The unusual env gene of ALV-J, with low homology to other subgroups of ALVs, is associated with its unique pathogenesis. However, th...

authors： Li T,Xie J,Yao X,Zhang J,Li C,Ren D,Li L,Xie Q,Shao H,Qin A,Ye J

更新日期：2021-12-01 00:00:00